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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature immunology - 08 Dec 2013

Ramond C, Berthault C, Burlen-Defranoux O, de Sousa AP, Guy-Grand D, Vieira P, Pereira P, Cumano A

Link to Pubmed [PMID] – 24317038

Nat. Immunol. 2014 Jan;15(1):27-35

The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter of considerable debate. Here we found that thymopoiesis was initiated by a first wave of T cell lineage-restricted progenitor cells with limited capacity for population expansion but accelerated differentiation into mature T cells. They gave rise to αβ and γδ T cells that constituted Vγ3(+) dendritic epithelial T cells. Thymopoiesis was subsequently maintained by less-differentiated progenitor cells that retained the potential to develop into B cells and myeloid cells. In that second wave, which started before birth, progenitor cells had high proliferative capacity but delayed differentiation capacity and no longer gave rise to embryonic γδ T cells. Our work reconciles conflicting hypotheses on the nature of thymus-settling progenitor cells.

http://www.ncbi.nlm.nih.gov/pubmed/24317038