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© Research
Publication : Journal of immunology (Baltimore, Md. : 1950)

Two major classes of mitogen-reactive B lymphocytes defined by life span

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 01 Jan 1986

Freitas AA, Rocha B, Coutinho AA

Link to Pubmed [PMID] – 3510249

J. Immunol. 1986 Jan;136(2):466-9

The relative numbers of short- and long-lived mitogen-reactive B cells in the peripheral pool were evaluated by studying the decay of lipopolysaccharide (LPS)-reactive B lymphocytes in LPS nonresponder, histocompatible hosts for periods of up to 3 wk after cell transfer. The results obtained demonstrate the existence of two major classes of mitogen-reactive B cells defined by life span. The “short-lived” cell component comprises about 80 to 90% of the reactive cells and decays with a life expectancy of 18 to 24 hr. The long-lived cell component, with life expectancies of 10 to 20 days, comprises about 10 to 20% of the reactive cells and is preferentially enriched in circulating B cells. The present ratio for short- and long-lived B cells implies a highly dynamic state for the immune system which must be advantageous in the selection of available repertoires.

http://www.ncbi.nlm.nih.gov/pubmed/3510249