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© Research
Publication : Expert review of anti-infective therapy

Treatment of HBV-related cirrhosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert review of anti-infective therapy - 01 Jun 2009

Vallet-Pichard A, Mallet V, Costentin CE, Pol S

Link to Pubmed [PMID] – 19485793

Expert Rev Anti Infect Ther 2009 Jun;7(5):527-35

The goal of antiviral therapy in HBV cirrhotic patients is to prevent progression of the disease to decompensated cirrhosis, end-stage liver disease, hepatocellular carcinoma and death. This goal can be achieved if HBV replication can be suppressed, leading to biochemical remission, histological improvement and prevention of complications. If finite treatment with pegylated interferon is not contraindicated in compensated cirrhosis, long-term treatment with nucleoside/nucleotide analogues is recommended in patients with HBV-related cirrhosis, especially in decompensated cirrhosis. Patients with cirrhosis require careful monitoring to detect resistance and prevent flares, and also to screen for hepatocellular carcinoma, portal hypertension and liver failure.

https://www.ncbi.nlm.nih.gov/pubmed/19485793