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© Research
Publication : BMC genomics

Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo

Team: Biomics
Team: Lymphocytes and Immunity
Member: Béatrice Regnault
Member: Ana Cumano
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC genomics - 08 Dec 2010

Lagha M, Sato T, Regnault B, Cumano A, Zuniga A, Licht J, Relaix F, Buckingham M

Link to Pubmed [PMID] – 21143873

BMC Genomics 2010;11:696

Pax3 is a key upstream regulator of the onset of myogenesis, controlling progenitor cell survival and behaviour as well as entry into the myogenic programme. It functions in the dermomyotome of the somite from which skeletal muscle derives and in progenitor cell populations that migrate from the somite such as those of the limbs. Few Pax3 target genes have been identified. Identifying genes that lie genetically downstream of Pax3 is therefore an important endeavour in elucidating the myogenic gene regulatory network.

http://www.ncbi.nlm.nih.gov/pubmed/21143873