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© Institut Pasteur
Cryptococcus neoformans
Publication : Biochemical and biophysical research communications

The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum–new tools for designing specific inhibitors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemical and biophysical research communications - 21 Oct 2009

Bahia D, Oliveira LM, Lima FM, Oliveira P, Silveira JF, Mortara RA, Ruiz JC

Link to Pubmed [PMID] – 19852933

Biochem. Biophys. Res. Commun. 2009 Dec;390(3):963-70

Phosphatidylinositol (PI) kinases are at the heart of one of the major pathways of intracellular signal transduction. Herein, we present the first report on a survey made by similarity searches against the five human pathogenic trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum genomes available to date for phosphatidylinositol- and related-kinases (TryPIKs). In addition to generating a panel called “The TryPIKinome”, we propose a model of signaling pathways for these TryPIKs. The involvement of TryPIKs in fundamental pathways, such as intracellular signal transduction and host invasion processes, makes the study of TryPIKs an important area for further inquiry. New subtype-specific inhibitors are expected to work on individual members of the PIK family and, therefore, can presumably neutralize trypanosomatid invasion processes.

https://www.ncbi.nlm.nih.gov/pubmed/19852933