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© Thibaut Brunet
C. flexa colonies fixed at different stages of inversion
Publication : Developmental cell

The Origin of Animal Multicellularity and Cell Differentiation.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental cell - 23 Oct 2017

Brunet T, King N,

Link to Pubmed [PMID] – 29065305

Link to DOI – S1534-5807(17)30769-410.1016/j.devcel.2017.09.016

Dev Cell 2017 10; 43(2): 124-140

Over 600 million years ago, animals evolved from a unicellular or colonial organism whose cell(s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar collar. Using principles from evolutionary cell biology, we reason that the transition to multicellularity required modification of pre-existing mechanisms for extracellular matrix synthesis and cytokinesis. We discuss two hypotheses for the origin of animal cell types: division of labor from ancient plurifunctional cells and conversion of temporally alternating phenotypes into spatially juxtaposed cell types. Mechanistic studies in diverse animals and their relatives promise to deepen our understanding of animal origins and cell biology.

https://pubmed.ncbi.nlm.nih.gov/29065305