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  • tool
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  • Pharmacist
  • PhD Student
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  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Publication : Nature reviews. Microbiology

The highly diverse antiphage defence systems of bacteria.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Microbiology - 01 Oct 2023

Georjon H, Bernheim A

Link to Pubmed [PMID] – 37460672

Link to DOI – 10.1038/s41579-023-00934-x

Nat Rev Microbiol 2023 Oct; 21(10): 686-700

Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing arms race has led bacteria to develop a vast antiphage arsenal. The development of high-throughput screening methods expanded our knowledge of defence systems from a handful to more than a hundred systems, unveiling many different molecular mechanisms. These findings reveal that bacterial immunity is much more complex than previously thought. In this Review, we explore recently discovered bacterial antiphage defence systems, with a particular focus on their molecular diversity, and discuss the ecological and evolutionary drivers and implications of the existing diversity of antiphage defence mechanisms.