Link to Pubmed [PMID] – 30308174
Link to DOI – S0896-6273(18)30840-710.1016/j.neuron.2018.09.038
Neuron 2018 10; 100(1): 9-11
Cardiovascular dysfunction becomes recognized as a risk for dementia. In this issue of Neuron, Park et al. (2018) report the age-related, brain endothelial-specific upregulation of acid sphingomyelinase (ASM), leading to blood-brain barrier malfunction, neurodegeneration, and memory deficits that were mitigated by ASM inhibition in mice.