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© Research
Publication : Neuron

The Fountain of Youth: It’s All in Our Veins.

Member: Amaia Dominguez-Belloso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuron - 10 Oct 2018

Dominguez-Belloso A, Liebner S,

Link to Pubmed [PMID] – 30308174

Link to DOI – S0896-6273(18)30840-710.1016/j.neuron.2018.09.038

Neuron 2018 10; 100(1): 9-11

Cardiovascular dysfunction becomes recognized as a risk for dementia. In this issue of Neuron, Park et al. (2018) report the age-related, brain endothelial-specific upregulation of acid sphingomyelinase (ASM), leading to blood-brain barrier malfunction, neurodegeneration, and memory deficits that were mitigated by ASM inhibition in mice.