Link to Pubmed [PMID] – 3487461
Eur. J. Immunol. 1986 Jul;16(7):871-4
The concentration of IgG2a in the serum of C57BL/6 mice suppressed for the production of IgG2a was measured over a period of 3 months after suppression. The elimination of a minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential decay with a half-life of 6-8 days. A monoclonal IgG2a antibody injected into suppressed or normal mice is eliminated from the serum in the same fashion. We conclude that there are few, if any, “long-lived” IgG2a molecules present in the serum of C57BL/6 mice under physiological conditions.