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© A-M. Pais-Correia, M-I. Thoulouze, A. Alcover, A. Gessain
Mise en évidence de structures de type "biofilm ", formées par le rétrovirus HTLV-1 générés par des cellules infectées (cellules du haut), qui ont été transmis à un autre lymphocyte (cellule du bas). Micrographie en microscopie électronique à balayage. Image colorisée.
Publication : Nature communications

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 01 Sep 2021

Marlin R, Godot V, Cardinaud S, Galhaut M, Coleon S, Zurawski S, Dereuddre-Bosquet N, Cavarelli M, Gallouët AS, Maisonnasse P, Dupaty L, Fenwick C, Naninck T, Lemaitre J, Gomez-Pacheco M, Kahlaoui N, Contreras V, Relouzat F, Fang RHT, Wang Z, Ellis J, Chapon C, Centlivre M, Wiedemann A, Lacabaratz C, Surenaud M, Szurgot I, Liljeström P, Planas D, Bruel T, Schwartz O, Werf SV, Pantaleo G, Prague M, Thiébaut R, Zurawski G, Lévy Y, Grand RL,

Link to Pubmed [PMID] – 34471122

Link to DOI – 10.1038/s41467-021-25382-0

Nat Commun 2021 09; 12(1): 5215

Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may have distinct advantages when immunizing vulnerable individuals, children and pregnant women. Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. Such vaccination significantly improves protection against a new high-dose virulent challenge versus that in non-vaccinated convalescent animals.

https://pubmed.ncbi.nlm.nih.gov/34471122