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© Research
Publication : Journal of immunology (Baltimore, Md. : 1950)

Taming the beast within: regulation of innate lymphoid cell homeostasis and function

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 01 Nov 2013

Xu W, Di Santo JP

Link to Pubmed [PMID] – 24141855

J. Immunol. 2013 Nov;191(9):4489-96

Although substantial parallels have been made between transcription factor regulation of cytokine production by innate lymphoid cell (ILC) and Th cell subsets, we are still learning how ILC subsets are regulated during immune responses. Critical factors that promote ILC development and stimulate their effector functions have been identified, but mechanisms that control their homeostasis and downregulate their cytokine secretion remain poorly understood. In this review, we consider some of the potential positive and negative regulators of ILC homeostasis and function in physiological and pathological conditions.

http://www.ncbi.nlm.nih.gov/pubmed/24141855