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© Michaela Muller-Trutwin
HIV
Publication : Journal of cellular and molecular medicine

T regulatory cells: aid or hindrance in the clearance of disease?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of cellular and molecular medicine - 01 Nov 2007

Coleman CA, Muller-Trutwin MC, Apetrei C, Pandrea I

Link to Pubmed [PMID] – 18205702

J. Cell. Mol. Med. 2007 Nov-Dec;11(6):1291-325

CD4+ CD25+ T regulatory cells (Tregs) are classified as a subset of T cells whose role is the suppression and regulation of immune responses to self and non-self. Since their discovery in the early 1970s, the role of CD4+ CD25+ Tregs in both autoimmune and infectious disease has continued to expand. This review examines the recent advances on the role CD4+ CD25+ Tregs may be playing in various diseases regarding progression or protection. In addition, advances made in the purification and manipulation of CD4+ CD25+ Tregs using new cell markers, techniques and antibodies are discussed. Ultimately, an overall understanding of the exact mechanism which CD4+ CD25+ Tregs implement during disease progression will enhance our ability to manipulate CD4+ CD25+ Tregs in a clinically beneficial manner.

https://www.ncbi.nlm.nih.gov/pubmed/18205702