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© Valérie Choumet
Mosquitoes were orally infected with the chikungunya virus. Midguts were dissected at day 5 post-infection, fixed and permeabilised. Virus is shown in red (anti-E2 protein, cyanine 3), the actin network in green (phalloidin 548) and nuclei in blue (DAPI).
Publication : Carbohydrate research

Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1

Team: Chemistry of Biomolecules
Member: Laurence Mulard
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Carbohydrate research - 01 Jun 1994

Mulard LA, Kovác P, Glaudemans CP

Link to Pubmed [PMID] – 7518745

Carbohydr. Res. 1994 Jun;259(1):21-34

The synthesis is reported of galactopyranose nucleophiles monofluorinated at positions 3, 4, or 6 and protected by 4,6-O-benzylidene, 3,6-di-O-benzyl, or 3,4-O-isopropylidene groups, respectively. The condensation of these nucleophiles with 2,3,4-tri-O-benzoyl-alpha-L-rhamnosyl bromide gave, after deprotection, the disaccharide analogues of methyl O-alpha-L-rhamnopyranosyl-(1–>2)-alpha-D-galactopyranoside, monofluorinated at position 3, 4, or 6 of the galactoside residue.