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© Research
Publication : Synthesis

Synthesis of 2,6-Substituted-7-(Het)aryl-7-deazapurine Nucleobases (2,4-Disubstituted-5-(Het)aryl-pyrrolo[2,3-d]pyrimidines

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Synthesis - 01 Oct 2017

Sabat, N.; Smolén. S.; Nauš, P.; Perlíková. P.; Cebová. M.; Poštová Slavětínská, L.; Hocek, M.

Link to DOI – 10.1055/s-0036-1588443

Synthesis. 2017, 49, 4623 – 4650

A series of 7-(het)aryl-7-deazapurine nucleobases (5-[(het)aryl]-2,4-disubstituted 7H-pyrrolo[2,3-d]pyrimidines) bearing NH2, OMe, SMe, or Me groups at position 6 and H, NH2, or Me at position 2 were prepared by the aqueous Suzuki–Miyaura cross coupling reactions from SEM-protected 7-iodo-7-deazapurines with (het)arylboronic acids followed by deprotection. The 6-methoxy derivatives were further transformed into 7-deazahypoxanthines or 7-deazaguanines by O-demethylation reactions. Unlike their ribonucleoside counterparts, the 7-deazapurine nucleobases did not exert any significant cytostatic or antiviral effects.