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© Research
Publication : Agents and actions

Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether)

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Agents and actions - 01 Dec 1981

Ténce M, Michel E, Coeffier E, Polonsky J, Godfroid JJ, Benveniste J

Link to Pubmed [PMID] – 7340440

Agents Actions 1981 Dec;11(6-7):558-9

Platelet-activating factor (PAF-acether), a mediator of anaphylaxis and inflammation, is a 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine. Some analogs of PAF-acether were prepared by total synthesis or by partial synthesis from commercially available phospholipids and tested for platelet aggregating activity. This study indicated that the ether linkage at the position 1 of sn-glycerol and the short acyl chain at position 2 are structural features required for biological activity.

https://www.ncbi.nlm.nih.gov/pubmed/7340440