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© Institut Pasteur
Cristaux de cellulase, enzyme purifiée de Clostridium thermocellum permettant la digestion de la cellulose. Image colorisée.
Publication : Bioorganic & medicinal chemistry

Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues

Team: Group : Chemistry and Biocatalysis
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioorganic & medicinal chemistry - 12 Dec 2006

Prado S, Janin YL, Saint-Joanis B, Brodin P, Michel S, Koch M, Cole ST, Tillequin F, Bost PE

Link to Pubmed [PMID] – 17208445

Bioorg. Med. Chem. 2007 Mar;15(5):2177-86

We recently reported that 3,3-dimethyl-3H-benzofuro[3,2,f][1]-benzopyran and its hydrogenated analogue are selective in vitro inhibitors of mycobacterial growth. However, their lack of in vivo activity on a murine model of Mycobacterium tuberculosis infection due to their poor bioavailability led to a structure-activity relationship investigation. We wish to report here the preparation of some structural analogues along with their biological effect on the growth of Mycobacterium smegmatis, M. tuberculosis, as well as on VERO cells for the most active compound.