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© Research
Publication : Infection and immunity

Susceptibilities of Cryptococcus neoformans strains to platelet binding in vivo and to the fungicidal activity of thrombin-induced platelet microbicidal proteins in vitro

Team: Archived: Molecular Mycology
Member: Françoise Dromer
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Feb 2001

Nail S, Robert R, Dromer F, Marot-Leblond A, Senet JM

Link to Pubmed [PMID] – 11160027

Infect. Immun. 2001 Feb;69(2):1221-5

In this study we investigated the interactions between capsular and acapsular strains of Cryptococcus neoformans and blood platelets. In vivo microscopic observation of blood samples from mice inoculated with C. neoformans yeast cells demonstrated that encapsulated and nonencapsulated yeast cells disappeared quickly from the bloodstream and that platelets were attached solely to yeast cells of the nonencapsulated strains. In vitro we observed that only the acapsular strains were susceptible to the fungicidal activity of thrombin-induced platelet microbicidal proteins.