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© Research
Publication : Trends in biotechnology

Structural instability of plasmid biopharmaceuticals: challenges and implications

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in biotechnology - 03 Aug 2009

Oliveira PH, Prather KJ, Prazeres DM, Monteiro GA

Link to Pubmed [PMID] – 19656584

Trends Biotechnol. 2009 Sep;27(9):503-11

The global increase in the number of applications involving therapeutic plasmid DNA (pDNA) is creating a need for large amounts of highly stable and purified molecules. One of the main obstacles during the developmental stages of a new therapeutic DNA molecule involves tackling a wide array of structural instability events occurring in/with pDNA and therefore assuring its structural integrity. This review focuses on major instability determinants in pDNA. Their elimination could be considered an important step towards the design of safer and more efficient plasmid molecules. Particular emphasis is given to mutations triggered by the presence of repeated sequences, instability events occurring during plasmid intracellular routing, instability mediated by insertion sequences and host genome integration.

http://www.ncbi.nlm.nih.gov/pubmed/19656584