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© Research
Publication : Malaria journal

Spatial distribution of G6PD deficiency variants across malaria-endemic regions

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Anavaj Sakuntabhai
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Malaria journal - 15 Nov 2013

Howes RE, Dewi M, Piel FB, Monteiro WM, Battle KE, Messina JP, Sakuntabhai A, Satyagraha AW, Williams TN, Baird JK, Hay SI

Link to Pubmed [PMID] – 24228846

Malar. J. 2013;12:418

Primaquine is essential for malaria control and elimination since it is the only available drug preventing multiple clinical attacks by relapses of Plasmodium vivax. It is also the only therapy against the sexual stages of Plasmodium falciparum infectious to mosquitoes, and is thus useful in preventing malaria transmission. However, the difficulties of diagnosing glucose-6-phosphate dehydrogenase deficiency (G6PDd) greatly hinder primaquine’s widespread use, as this common genetic disorder makes patients susceptible to potentially severe and fatal primaquine-induced haemolysis. The risk of such an outcome varies widely among G6PD gene variants.