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© Research
Publication : Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Sorting DNA with asymmetry: a new player in gene regulation?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 01 May 2013

Evano B, Tajbakhsh S

Link to Pubmed [PMID] – 23681656

Chromosome Res. 2013 May;21(3):225-42

In recent years, our views on how DNA and genes are organised and regulated have evolved significantly. One example is provided by reports that single DNA strands in the double helix could carry distinct forms of information. That chromatids carrying old and nascently replicated DNA strands are recognised by the mitotic machinery, then segregated in a concerted way to distinct daughter cells after cell division is remarkable. Notably, this phenomenon in several cases has been associated with the cell fate choice of resulting daughter cells. Here, we review the evidence for asymmetric or template DNA strand segregation in mammals with a focus on skeletal muscle.

http://www.ncbi.nlm.nih.gov/pubmed/23681656