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© Research
Publication : FEMS microbiology letters

Some safety aspects of Salmonella vaccines for poultry: in vivo study of the genetic stability of three Salmonella typhimurium live vaccines

Team: Archived: Molecular Genetics of RNA Viruses
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEMS microbiology letters - 01 Nov 2000

Barbezange C, Ermel G, Ragimbeau C, Humbert F, Salvat G

Link to Pubmed [PMID] – 11040436

FEMS Microbiol. Lett. 2000 Nov;192(1):101-6

Live vaccine strains of Salmonella should be avirulent, immunogenic and genetically stable. Some isolates of three commercially available live vaccine strains of Salmonella typhimurium, sampled during a study on their persistence in a vaccinated flock of chickens, were analyzed for genetic stability using macrorestriction analysis of their genome. Two out of the three vaccine strains showed genetic instabilities. Two of the 51 isolates of Zoosaloral vaccine strain and nine of the 32 analyzed isolates of chi(3985), a genetically modified organism, were variants and showed different macrorestriction profiles.