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© Research
Publication : Biochimie

Solution structure of the orphan nuclear receptor rev-erb beta response element by 1H, 31P NMR and molecular simulation*

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 01 Aug 2000

Castagné C, Terenzi H, Zakin MM, Delepierre M

Link to Pubmed [PMID] – 11018291

Biochimie 2000 Aug;82(8):739-48

Rev-erb beta is an orphan receptor that binds as a homodimer or as a monomer to DNA. The solution structure of the non-palindromic 15 bp DNA duplex d(TAGAATGTAGGTCAG), the response element of Rev-erb beta for monomeric binding, was determined by 1H and 31P NMR, energy minimization with NMR-derived restraints for distances and NOE back-calculation methods. The refined final structures have the typical overall features of B-type DNA. However, titration of this 15 bp duplex with ReDBD, the DNA binding domain of Rev-erb beta, showed large shifts of imino protons and 31P signals, suggesting major conformational changes.

http://www.ncbi.nlm.nih.gov/pubmed/11018291