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© Research
Publication : Biochemistry

Solution structure of a homopyrimidine: homopurine dodecamer encoded by the HIV-1 envelope gene: NMR and molecular simulation studies

Team: Archived: Nuclear Magnetic Resonance Of Biomolecules
Member: Muriel Delepierre
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemistry - 23 May 1995

Sodano P, Hartmann B, Rose T, Wain-Hobson S, Delepierre M

Link to Pubmed [PMID] – 7756322

Biochemistry 1995 May;34(20):6900-10

The solution structure of the nonpalindromic dodecanucleotide homopyrimidine:homopurine, d(5′-TTTCTCCTTTCT):d(5′-AGAAAGGAGAAA), was determined by two-dimensional nuclear magnetic resonance spectroscopy combined with molecular simulation. The dodecamer sequence studied was found within the HIV-1 envelope sequence and had all four Gs substituted by A in two hypermutants. A set of low-energy B-DNA conformations satisfying the quantitative NOE data were obtained. These highly related structure had neither peculiar helical parameters for the base pairs nor axis curvature. Analysis of the dihedral angles (epsilon-zeta) suggests that the A stretches flanking the GpA dinucleotides were more flexible.