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© Michaela Muller-Trutwin
HIV
Publication : Journal of medical primatology

SIVcpz from a naturally infected Cameroonian chimpanzee: biological and genetic comparison with HIV-1 N

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of medical primatology - 01 Aug 2000

Müller-Trutwin MC, Corbet S, Souquière S, Roques P, Versmisse P, Ayouba A, Delarue S, Nerrienet E, Lewis J, Martin P, Simon F, Barré-Sinoussi F, Mauclère P

Link to Pubmed [PMID] – 11085579

J. Med. Primatol. 2000 Aug;29(3-4):166-72

Thus far, simian immunodeficiency virus from chimpanzees (SIVcpz) genomes have been characterized as Pan troglodytes troglodytes and show a strong relation with human immunodeficiency virus (HIV)-1 N in their env genes. We fully characterized another SIVcpz from P. t. troglodytes. This chimpanzee (Cam5) was, as was also the host of SIVcpz-cam3, wild born in Cameroon, a region where all three groups of HIV-1 (M, N and O) co-occur. In contrast to other SIVcpz, SIVcpz-cam5 was isolated immediately after the rescue of the animal. Our data demonstrate that SIVcpz-cam5, like SIVcpz-cam3, grows easily on human peripheral blood mononuclear cells (PBMCs) and uses CCR5 as a co-receptor similar to HIV-1 N YBF30. Phylogenetic analysis based on the entire env gene shows that SIVcpz-cam5 falls into the same unique subcluster as HIV-1 N YBF30, SIVcpz-cam3 and SIVcpz-US. A phylogenetic relationship was also found with the vif gene of HIV-1 N. This study provides proof that HIV-1 N related viruses circulate in wild P. t. troglodytes.

https://www.ncbi.nlm.nih.gov/pubmed/11085579