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© Research
Publication : Antibiotics (Basel, Switzerland)

Silver and Antibiotic, New Facts to an Old Story

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antibiotics (Basel, Switzerland) - 22 Aug 2018

Barras F, Aussel L, Ezraty B

Link to Pubmed [PMID] – 30135366

Antibiotics (Basel) 2018 Aug;7(3)

The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics.

https://www.ncbi.nlm.nih.gov/pubmed/30135366