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© Automated cell tracking in a Parhyale hawaiensis embryo. Wolff et al., 2018.
Publication : Nature microbiology

Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature microbiology - 01 Nov 2019

Tinevez JY, Arena ET, Anderson M, Nigro G, Injarabian L, André A, Ferrari M, Campbell-Valois FX, Devin A, Shorte SL, Sansonetti PJ, Marteyn BS,

Link to Pubmed [PMID] – 31383999

Link to DOI – 10.1038/s41564-019-0525-3

Nat Microbiol 2019 11; 4(11): 2001-2009

Pathogenic enterobacteria face various oxygen (O2) levels during intestinal colonization from the O2-deprived lumen to oxygenated tissues. Using Shigella flexneri as a model, we have previously demonstrated that epithelium invasion is promoted by O2 in a type III secretion system-dependent manner. However, subsequent pathogen adaptation to tissue oxygenation modulation remained unknown. Assessing single-cell distribution, together with tissue oxygenation, we demonstrate here that the colonic mucosa O2 is actively depleted by S. flexneri aerobic respiration-and not host neutrophils-during infection, leading to the formation of hypoxic foci of infection. This process is promoted by type III secretion system inactivation in infected tissues, favouring colonizers over explorers. We identify the molecular mechanisms supporting infectious hypoxia induction, and demonstrate here how enteropathogens optimize their colonization capacity in relation to their ability to manipulate tissue oxygenation during infection.