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© Therese Couderc, Marc Lecuit
Publication : Genes & development

Sfp1 regulates transcriptional networks driving cell growth and division through multiple promoter-binding modes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genes & development - 25 Feb 2019

Albert B, Tomassetti S, Gloor Y, Dilg D, Mattarocci S, Kubik S, Hafner L, Shore D

Link to Pubmed [PMID] – 30804227

Genes Dev. 2019 Mar;33(5-6):288-293

The yeast Sfp1 protein regulates both cell division and growth but how it coordinates these processes is poorly understood. We demonstrate that Sfp1 directly controls genes required for ribosome production and many other growth-promoting processes. Remarkably, the complete set of Sfp1 target genes is revealed only by a combination of ChIP (chromatin immunoprecipitation) and ChEC (chromatin endogenous cleavage) methods, which uncover two promoter binding modes, one requiring a cofactor and the other a DNA-recognition motif. Glucose-regulated Sfp1 binding at cell cycle “START” genes suggests that Sfp1 controls cell size by coordinating expression of genes implicated in mass accumulation and cell division.

https://www.ncbi.nlm.nih.gov/pubmed/30804227