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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Publication : Journal of biology

Scribble at the crossroads

Team: Cell Polarity, Migration And Cancer
Member: Sandrine Etienne-Manneville
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of biology - 29 Dec 2009

Etienne-Manneville S

Link to Pubmed [PMID] – 20053305

J. Biol. 2009;8(12):104

Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.

http://www.ncbi.nlm.nih.gov/pubmed/20053305