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© Melanie Blokesch, EPFL
Flagellated Vibrio cholerae
Publication : Antimicrobial agents and chemotherapy

SatR is a repressor of fluoroquinolone efflux pump SatAB

Team: Bacterial Genome Plasticity
Member:
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 06 May 2013

Escudero JA, San Millan A, Montero N, Gutierrez B, Ovejero CM, Carrilero L, González-Zorn B

Link to Pubmed [PMID] – 23650171

Antimicrob. Agents Chemother. 2013 Jul;57(7):3430-3

Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.