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© Adeline Mallet
Nématodes Caenorhabditis elegans en microscopie électronique à balayage.
Publication : Journal of acquired immune deficiency syndromes (1999)

Rosuvastatin is effective to decrease CD8 T-cell activation only in HIV-infected patients with high residual T-cell activation under antiretroviral therapy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of acquired immune deficiency syndromes (1999) - 02 Nov 2015

Weiss L, Chevalier MF, Assoumou L, Paul JL, Alhenc-Gelas M, Didier C, Taibi S, Manea M, Campa P, Girard PM, Costagliola D,

Link to Pubmed [PMID] – 26536319

J. Acquir. Immune Defic. Syndr. 2015 Nov;

OBJECTIVE: The aim of the trial was to evaluate in patients under ART the effect of rosuvastatin on cellular and soluble markers of immune activation/inflammation, as well as to identify patients who better benefit from statin administration.

METHODS: IMEA-043-CESAR was a Phase II open-label pilot trial that enrolled patients under suppressive ART and CD4 <500/mm. Patients received rosuvastatin (20mg/d) for 12 weeks 3 months. The primary outcome was the variation at week 12 (W12) in the proportion of CD38+HLA-DR+CD8+T lymphocytes. Secondary outcomes included evolution of other markers of T-cell activation and of inflammatory biomarkers between baseline, W12 and W24.

RESULTS: Fifty patients were enrolled; endpoints were available for 43 patients. When considering all patients, the proportion of CD38+HLA-DR+CD8+ T cells did not significantly decline throughout the follow-up. However, the proportion of CD38+CD8+T cells significantly decreased at W12 (median percentage change of -22.2% (-32.3;+1.4)). Principal component analysis allowed identification of 3 groups of patients based on their baseline activation/inflammation profiles, one group with elevated levels of CD8 T-cell activation, a small group with high levels of systemic inflammation and low levels of T-cell activation. Half of the patients exhibited relatively low levels of inflammation and activation. The proportion of activated CD8 T cells significantly decreased only in the particular group of patients with high baseline CD8 T-cell activation.

CONCLUSION: This study shows that combining rosuvastatin with effective ART can result in a sustained decrease in CD8 T-cell activation and highlights the importance of identifying patients who can benefit from specific immunotherapeutic strategies.

http://www.ncbi.nlm.nih.gov/pubmed/26536319