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Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens

The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates

© Institut Pasteur

Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).

Publication : Virus research

RNA silencing in viral infections: insights from poliovirus

Team: Viruses and RNA Interference

Member: Carla Saleh

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in Virus research - 01 Jun 2004

Saleh MC, Van Rij RP, Andino R

Link to Pubmed [PMID] – 15068875

Virus Res. 2004 Jun;102(1):11-7

RNA interference or RNA silencing is a dsRNA guided mechanism that mediates sequence specific degradation of RNA. The recent demonstration that RNA interference can be used to inhibit virus replication has initiated an exciting field of research: first, as a potential novel antiviral therapeutic approach and, second, as a tool for dissecting virus-host interactions. Here we review and discuss the current data and perspectives on the use of RNA interference in the study of poliovirus as a model for positive strand RNA viruses.

Published on: 01 Jun 2004