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© Research
Publication : Molecular and cellular biology

Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular and cellular biology - 01 Jun 2004

Rougeulle C, Chaumeil J, Sarma K, Allis CD, Reinberg D, Avner P, Heard E

Link to Pubmed [PMID] – 15169908

Mol. Cell. Biol. 2004 Jun;24(12):5475-84

Histone H3 tail modifications are among the earliest chromatin changes in the X-chromosome inactivation process. In this study we investigated the relative profiles of two important repressive marks on the X chromosome: methylation of H3 lysine 9 (K9) and 27 (K27). We found that both H3K9 dimethylation and K27 trimethylation characterize the inactive X in somatic cells and that their relative kinetics of enrichment on the X chromosome as it undergoes inactivation are similar. However, dynamic changes of H3K9 and H3K27 methylation on the inactivating X chromosome compared to the rest of the genome are distinct, suggesting that these two modifications play complementary and perhaps nonredundant roles in the establishment and/or maintenance of X inactivation. Furthermore, we show that a hotspot of H3K9 dimethylation 5′ to Xist also displays high levels of H3 tri-meK27. However, analysis of this region in G9a mutant embryonic stem cells shows that these two methyl marks are dependent on different histone methyltransferases.

http://www.ncbi.nlm.nih.gov/pubmed/15169908