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© Research
Publication : Science (New York, N.Y.)

RNA interference is essential for cellular quiescence

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 13 Oct 2016

Roche B, Arcangioli B, Martienssen RA

Link to Pubmed [PMID] – 27738016

Science 2016 11;354(6313)

Quiescent cells play a predominant role in most organisms. Here we identify RNA interference (RNAi) as a major requirement for quiescence (G phase of the cell cycle) in Schizosaccharomyces pombe RNAi mutants lose viability at G entry and are unable to maintain long-term quiescence. We identified suppressors of G defects in cells lacking Dicer (dcr1Δ), which mapped to genes involved in chromosome segregation, RNA polymerase-associated factors, and heterochromatin formation. We propose a model in which RNAi promotes the release of RNA polymerase in cycling and quiescent cells: (i) RNA polymerase II release mediates heterochromatin formation at centromeres, allowing proper chromosome segregation during mitotic growth and G entry, and (ii) RNA polymerase I release prevents heterochromatin formation at ribosomal DNA during quiescence maintenance. Our model may account for the codependency of RNAi and histone H3 lysine 9 methylation throughout eukaryotic evolution.

https://www.ncbi.nlm.nih.gov/pubmed/27738016