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© Perrine Bomme, Guillaume Duménil, Jean-Marc Panaud.
Coloured scanning electron micrograph (SEM) of Neisseria meningitidis on epithelial cells
Publication : The Journal of antimicrobial chemotherapy

Emergence of meningococci with reduced susceptibility to third-generation cephalosporins

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of antimicrobial chemotherapy - 12 Oct 2016

Deghmane AE, Hong E, Taha MK

Link to Pubmed [PMID] – 27733517

J. Antimicrob. Chemother. 2017 01;72(1):95-98

OBJECTIVES: Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012.

METHODS: Invasive meningococcal isolates were typed by MLST and penA sequencing and their antibiotic susceptibility was tested.

RESULTS: Isolates with reduced susceptibility to C3Gs represented 2% of all invasive isolates from 2012-15, but were absent before. They harboured a new penA allele, penA327, that was also detected in isolates from urethritis cases and in gonococci.

CONCLUSIONS: Surveillance of these isolates should be enhanced as they may jeopardize the use of C3Gs in the management of invasive meningococcal disease.

https://www.ncbi.nlm.nih.gov/pubmed/27733517