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© Research
Publication : Nature neuroscience

Rewiring of hindlimb corticospinal neurons after spinal cord injury

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature neuroscience - 13 Dec 2009

Ghosh A, Haiss F, Sydekum E, Schneider R, Gullo M, Wyss MT, Mueggler T, Baltes C, Rudin M, Weber B, Schwab ME

Link to Pubmed [PMID] – 20010824

Nat. Neurosci. 2010 Jan;13(1):97-104

Little is known about the functional role of axotomized cortical neurons that survive spinal cord injury. Large thoracic spinal cord injuries in adult rats result in impairments of hindlimb function. Using retrograde tracers, we found that axotomized corticospinal axons from the hindlimb sensorimotor cortex sprouted in the cervical spinal cord. Mapping of these neurons revealed the emergence of a new forelimb corticospinal projection from the rostral part of the former hindlimb cortex. Voltage-sensitive dye (VSD) imaging and blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD fMRI) revealed a stable expansion of the forelimb sensory map, covering in particular the former hindlimb cortex containing the rewired neurons. Therefore, axotomized hindlimb corticospinal neurons can be incorporated into the sensorimotor circuits of the unaffected forelimb.

https://www.ncbi.nlm.nih.gov/pubmed/20010824