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© Research
Publication : Proceedings of the National Academy of Sciences of the United States of America

Resource competition as a mechanism for B cell homeostasis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 27 May 1997

McLean AR, Rosado MM, Agenes F, Vasconcellos R, Freitas AA

Link to Pubmed [PMID] – 9159153

Proc. Natl. Acad. Sci. U.S.A. 1997 May;94(11):5792-7

Cellular competition for survival signals offers a cogent and appealing mechanism for the maintenance of cellular homeostasis [Raff, M. C. (1992) Nature (London) 356, 397-400]. We present a theoretical and experimental investigation of the role of competition for resources in the regulation of peripheral B cell numbers. We use formal ecological competition theory, mathematical models of interspecific competition, and competitive repopulation experiments to show that B cells must compete to persist in the periphery and that antigen forms a part of the resources over which B cells compete.

http://www.ncbi.nlm.nih.gov/pubmed/9159153