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© Research
Publication : Current opinion in neurobiology

Regulation of neurogenesis in the adult and aging brain

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in neurobiology - 01 Dec 2018

Katsimpardi L, Lledo PM

Link to Pubmed [PMID] – 30077888

Curr. Opin. Neurobiol. 2018 Dec;53:131-138

Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to progeny throughout life in specific regions of the adult brain. Although NSCs were thought to merely represent a stem cell type in the brain, recent advances have demonstrated the incredible complexity of NSC identity and functions. Ranging between quiescence, activation and intermediary subtypes, NSCs choose their fate through their developmental inheritance, regional positioning within the niche, as well as dynamic transcriptional and metabolic states. The plasticity of their developmental program is reflected in the tremendous changes they undergo upon external environmental cues and extrinsic manipulations, and harnessing these potentials can open new avenues to fight against brain injury, neurodegenerative and age-related diseases.

https://www.ncbi.nlm.nih.gov/pubmed/30077888