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© Research
Publication : Developmental biology

Regulation and phylogeny of skeletal muscle regeneration

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental biology - 12 Aug 2017

Baghdadi MB, Tajbakhsh S

Link to Pubmed [PMID] – 28811217

Dev. Biol. 2018 01;433(2):200-209

One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury. In addition, numerous murine injury models are used to investigate the regeneration process, and some can lead to discrepancies in observed phenotypes. This review addresses these issues and provides an overview of some of the main regulatory cellular and molecular players involved in skeletal muscle repair.

https://www.ncbi.nlm.nih.gov/pubmed/28811217