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© Research
Publication : The Journal of infectious diseases

Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission

Team: Human Evolutionary Genetics
Member: Lluis Quintana-Murci
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 01 Jul 2008

Zhang J, Zhang X, Fu J, Bi Z, Arheart KL, Barreiro LB, Quintana-Murci L, Pahwa S, Liu H

Link to Pubmed [PMID] – 18510454

J. Infect. Dis. 2008 Jul;198(1):68-71

To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P=.007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1 transmission. These naturally occurring DC-SIGN neck-region variants were significantly more frequent in the Chinese population than in the US population (P <.001) and in a worldwide population (P=.006).