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© Research
Publication : Current opinion in microbiology

Properties of probiotic bacteria explored by proteomic approaches

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 30 May 2012

van de Guchte M, Chaze T, Jan G, Mistou MY

Link to Pubmed [PMID] – 22658701

Curr. Opin. Microbiol. 2012 Jun;15(3):381-9

The study of health-beneficial effects that probiotic bacteria can exert on humans and animals is at its beginning. Pending scientific questions include the identification of molecular markers of the health-promoting activity of specific strains, which may be used to select novel probiotic strains and to gain understanding of the mechanisms underlying their effects. In that perspective, the role of bacterial proteins must be evaluated, placing proteomics-based approaches at the core of the field. Until now, most proteomic analyses focused on the dynamics of abundant cytoplasmic proteins during adaptation of bacteria to conditions mimicking the gastro-intestinal tract environment. The development of in silico and experimental procedures allowing identification and quantification of surface-exposed and secreted proteins should boost our understanding of bacteria-host crosstalk.