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© Adeline Mallet
Nématodes Caenorhabditis elegans en microscopie électronique à balayage.
Publication : Molecular cell

Promoters recognized by forkhead proteins exist for individual 21U-RNAs

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular cell - 19 Jul 2012

Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A

Link to Pubmed [PMID] – 22819322

Mol. Cell 2012 Sep;47(5):734-45

C. elegans 21U-RNAs are equivalent to the piRNAs discovered in other metazoans and have important roles in gametogenesis and transposon control. The biogenesis and molecular function of 21U-RNAs and piRNAs are poorly understood. Here, we demonstrate that transcription of each 21U-RNA is regulated separately through a conserved upstream DNA motif. We use genomic analysis to show that this motif is associated with low nucleosome occupancy, a characteristic of many promoters that drive expression of protein-coding genes, and that RNA polymerase II is localized to this nucleosome-depleted region. We establish that the most conserved 8-mer sequence in the upstream region of 21U-RNAs, CTGTTTCA, is absolutely required for their individual expression. Furthermore, we demonstrate that the 8-mer is specifically recognized by Forkhead family (FKH) transcription factors and that 21U-RNA expression is diminished in several FKH mutants. Our results suggest that thousands of small noncoding transcription units are regulated by FKH proteins.

http://www.ncbi.nlm.nih.gov/pubmed/22819322