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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Publication : Current opinion in neurobiology

Polarity proteins in glial cell functions

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in neurobiology - 22 Oct 2008

Etienne-Manneville S

Link to Pubmed [PMID] – 18840525

Curr. Opin. Neurobiol. 2008 Oct;18(5):488-94

Glial cells, which include myelinating oligodendrocytes, Schwann cells and astrocytes, fulfil a large variety of functions that are critical for the development, functioning and regeneration of neurons. Some of these glial functions have been shown to require polarization of the intracellular machinery. Although the initial signals leading to glial cell polarization during development and in the adult are not completely elucidated, crucial molecules such as proteins of the extracellular matrix and their membrane receptors have been identified. A general picture of the intracellular signalling pathways controlling polarity in glial cells is also emerging and shows that highly conserved and ubiquitously expressed polarity proteins are involved.

http://www.ncbi.nlm.nih.gov/pubmed/18840525