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© Artur Scherf
Scanning Electron Microscopy of Red Blood Cell infected by Plasmodium falciparum.
Publication : International journal for parasitology

Plasmodium falciparum signal sequences: simply sequences or special signals?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal for parasitology - 01 Oct 2001

Nacer A, Berry L, Slomianny C, Mattei D

Link to Pubmed [PMID] – 11566304

Int. J. Parasitol. 2001 Oct;31(12):1371-9

The malaria parasite, Plasmodium falciparum, synthesises and exports several proteins inducing morphological and biochemical modifications of erythrocytes during the erythrocytic cycle. The protein trafficking machinery of the parasite is similar to that of other eukaryotic cells in several ways. However, some unusual features are also observed. The secretion of various polypeptides was inhibited when P. falciparum-infected erythrocytes were incubated with Brefeldin A. Immunoelectron microscopy studies revealed substantial morphological changes in the endoplasmic reticulum following exposure of parasitised erythrocytes to the drug. Immunofluorescence studies of Brefeldin A-treated parasites suggest that polypeptide sorting to different intracellular destinations begins at the endoplasmic reticulum. The parasite also secretes polypeptides by a Brefeldin A-insensitive route that bypasses the classical endoplasmic reticulum-Golgi complex pathway.

http://www.ncbi.nlm.nih.gov/pubmed/11566304