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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Experimental parasitology

Plasmodium falciparum: characterization of gene R45 encoding a trophozoite antigen containing a central block of six amino acid repeats

Team: Trypanosome Cell Biology
Member: Serge Bonnefoy
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Experimental parasitology - 01 Jun 1992

Bonnefoy S, Guillotte M, Langsley G, Mercereau-Puijalon O

Link to Pubmed [PMID] – 1350536

Exp. Parasitol. 1992 Jun;74(4):441-51

We describe here an antigen, called R45, expressed by the young trophozoites of Plasmodium falciparum. This antigen contains a block of tandem repeats of six amino acids which are recognized by sera from humans living in endemic areas. The R45 gene is located on chromosome 3. It is present in all strains examined and shows limited size polymorphism. The C-terminal unique region of the protein shows a strong homology with the catalytic domain of the serine protein kinases. Interestingly, the central repeats contain a large number of putative phosphorylation sites. The implications of these features are discussed.