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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins
Publication : International journal of pharmaceutics

Pharmacokinetic profiles of two tablet formulations of piroxicam

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of pharmaceutics - 13 May 2005

Rasetti-Escargueil C, Grangé V

Link to Pubmed [PMID] – 15847998

Int J Pharm 2005 May;295(1-2):129-34

There is considerable interest in developing new non-steroidal anti-inflammatory drugs (NSAIDs) formulations with faster onset of analgesic action like fast dissolving tablets. An open-label, randomized, single dose, crossover study with a 18 days washout period was conducted in 16 healthy volunteers to compare the pharmacokinetic profile of 20 mg piroxicam freeze-dried tablet (Proxalyoc, Cephalon) with that of 20 mg piroxicam capsule (Feldene, Pfizer). T(lag) with freeze-dried tablet was three times shorter than with capsule (21.6 min versus 59.4 min). Mean AUC(0-30 min), mean AUC(0-1 h), mean plasma concentrations at 15 min, 30 min and 1 h post-dose were significantly higher with the freeze-dried tablet than with the capsule, indicating that piroxicam was more rapidly absorbed from the freeze-dried tablet with higher plasma concentrations achieved at shorter intervals after dosing. The 90% confidence intervals of the ratios of means C(max), AUC(0-t), AUC(0-infinity) and T(1/2) all fell within the acceptance range of 0.8-1.25, demonstrating the bioequivalence of the two formulations. Although the bioavailability of the two formulations was similar, the administration of piroxicam as a freeze-dried tablet gave a much faster absorption rate during the first hour after dosing than the capsule formulation. This faster absorption is an obvious advantage for the treatment of acute episodes of pain.

https://www.ncbi.nlm.nih.gov/pubmed/15847998