Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : International immunology

Persistence of memory B cells in mice deprived of T cell help

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 01 Jan 1990

Vieira P, Rajewsky K

Link to Pubmed [PMID] – 2150759

Int. Immunol. 1990;2(6):487-94

The influence of T cell help on the induction, maintenance, and recall of B cell memory to a T cell-dependent antigen was studied in mice. The antigen was a hapten coupled to a protein carrier, and helper T cells were eliminated before, during, or after immunization by treatment of the animals with anti-CD4 antibodies. B cell memory was quantified in an adoptive cell transfer system, transferring B cells from the primed animals together with carrier-primed syngeneic T cells. Anti-CD4 treatment completely inhibited the induction of primary and secondary responses and of B cell memory. In contrast, it did not affect established B cell memory over a period of at least 6 weeks. Consequently, this suggests that within this time range B cell memory to a T cell-dependent antigen does not rely on the continuous recruitment of naive B cells into the memory compartment, and memory B cells need little or no (antigen-mediated) T cell help in order to persist.

http://www.ncbi.nlm.nih.gov/pubmed/2150759