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© Research
Publication : Genetic testing and molecular biomarkers

Partial microdeletions in the Y-chromosome AZFc region are not a significant risk factor for spermatogenic impairment in Tunisian infertile men

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genetic testing and molecular biomarkers - 25 Jun 2012

Ghorbel M, Gargouri SB, Zribi N, Abdallah FB, Cherif M, Keskes R, Chakroun N, Sellami A, McElreavey K, Fakhfakh F, Ammar-Keskes L

Link to Pubmed [PMID] – 22731643

Genet Test Mol Biomarkers 2012 Jul;16(7):775-9

Azoospermia factor (AZF) subdeletions were reported to be significant risk factors for spermatogenesis. In this study, we screened classical and partial microdeletions of the Y-chromosome AZF region in a group of 261 infertile men. Partial deletions were also screened in a control group of fertile men (n=124). In addition, Y haplogroups were analyzed in 24 gr/gr deleted patients. Among the 261 studied infertile men, seven subjects were found to have classical microdeletions. The most common partial deletion of AZFc (gr/gr) was observed in 13.02% of infertile men and in 12.90% of fertile men. The b1/b3 deletion was identified in 4.98% of infertile men and in 2.41% of fertile men. In addition, the b2/b3 deletion was identified in 1.53% of infertile patients but not in the control group. Our results suggest that partial AZFc deletions are not associated with spermatogenic failure in the Tunisian population.

http://www.ncbi.nlm.nih.gov/pubmed/22731643