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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.
Publication : Nucleic acids research

Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation

Team: Integrative Neurobiology of Cholinergic Systems
Member: Uwe Maskos
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleic acids research - 11 Apr 1992

Maskos U, Southern EM

Link to Pubmed [PMID] – 1579458

Nucleic Acids Res. 1992 Apr;20(7):1675-8

A novel method for the analysis of oligonucleotide-oligonucleotide interactions is described. Oligonucleotides of different sequence are synthesised in situ as stripes on the surface of a glass slide (see accompanying paper). Multiple hybridizations are then carried out on each oligonucleotide simultaneously to determine the dependence of oligonucleotide duplex formation on duplex length, base composition, hybridisation solvent and sequence complexity.