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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Immunological reviews

Organogenesis of peripheral lymphoid organs

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunological reviews - 01 Oct 2003

Nishikawa S, Honda K, Vieira P, Yoshida H

Link to Pubmed [PMID] – 12969311

Immunol. Rev. 2003 Oct;195:72-80

The discovery that lymphotoxin alpha (LTalpha) knockout mice lack peripheral lymphoid tissues reformed the study of organogenesis of peripheral lymphoid tissues from a research field that was solely descriptive and dependent on histological methods to one requiring all modern technologies. The concepts of inducer cells for organogenesis of peripheral lymphoid tissues as a separate hematopoietic lineage and of mesenchymal organizer cells have been established through this progress. These discoveries led to the comprehension of the basic framework of the events during organogenesis of peripheral lymphoid tissues. However, many important questions remain unanswered. This review discusses those questions which have arisen from our studies on the organogenesis of Peyer’s patches.

http://www.ncbi.nlm.nih.gov/pubmed/12969311