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© Research
Publication : Current opinion in microbiology

Order and disorder in bacterial genomes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 Oct 2004

Rocha EP

Link to Pubmed [PMID] – 15451508

Curr. Opin. Microbiol. 2004 Oct;7(5):519-27

The availability of sequenced bacterial genomes allows a deeper understanding of their organizational features that are related with fundamental cellular processes such as coordinated gene expression, chromosome replication and cell division. Nevertheless, recent genome comparisons and experimental work highlighted the fluidity of bacterial chromosomes, including genome rearrangements that imperil the selective features of chromosome order. As a result, the clash between elements generating rearrangements and chromosome organization is a classic case of evolutionary conflict.

http://www.ncbi.nlm.nih.gov/pubmed/15451508